apalutamide will decrease the extent or outcome of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with medications that happen to be CYP3A4 substrates can lead to lower exposure to those drugs.Having said that, While reviews of hab